Complex Regulation of Pulmonary Inflammation and Fibrosis by CCL18
نویسندگان
چکیده
منابع مشابه
Inflammation and Pulmonary Fibrosis
The development of pulmonary fibrosis is the end point of a wide range of respiratory diseases including organic and inorganic dust exposure, pulmonary infection, acute lung injury, radiation, the idiopathic interstitial pneumonias (IIP), and connective tissue diseases. The most common fibrotic lung disorder is idiopathic pulmonary fibrosis (IPF), an IIP with the histological appearance of usua...
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43 Introduction: Lymphedema, a common complication of cancer treatment, is characterized by 44 inflammation, fibrosis, and adipose deposition. We previously have shown that macrophage 45 infiltration is increased in mouse models of lymphedema. Because macrophages are regulators of 46 lymphangiogenesis and fibrosis, this study aimed to determine the role of these cells in lymphedema 47 using dep...
متن کاملRegulation of inflammation and fibrosis by macrophages in lymphedema.
Lymphedema, a common complication of cancer treatment, is characterized by inflammation, fibrosis, and adipose deposition. We have previously shown that macrophage infiltration is increased in mouse models of lymphedema. Because macrophages are regulators of lymphangiogenesis and fibrosis, this study aimed to determine the role of these cells in lymphedema using depletion experiments. Matched b...
متن کاملA vicious circle of alveolar macrophages and fibroblasts perpetuates pulmonary fibrosis via CCL18.
RATIONALE Recently, models of macrophage activation have been revised. Macrophages stimulated with Th2 cytokines have been classified as alternatively activated. OBJECTIVES This article examines the expression and regulation of CC chemokine ligand 18 (CCL18), a marker of alternative activation, by human alveolar macrophages (AMs). METHODS AM were obtained from bronchoalveolar lavage (BAL) f...
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CXC chemokine receptor 3 (CXCR3) is the receptor for the IFN-gamma-inducible C-X-C chemokines MIG/CXCL9, IP-10/CXCL10, and I-TAC/CXCL11. CXCR3 is expressed on activated immune cells and proliferating endothelial cells. The role of CXCR3 in fibroproliferation has not been investigated. We examined the role of CXCR3 in pulmonary injury and repair in vivo. CXCR3-deficient mice demonstrated increas...
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ژورنال
عنوان ژورنال: The American Journal of Pathology
سال: 2007
ISSN: 0002-9440
DOI: 10.2353/ajpath.2007.061167